Monday, August 5, 2013

Nextraction Energy announces loan facility amendment

Nextraction Energy Corp. (TSX VENTURE:NE) announces that it has entered into an amending agreement to extend the principal repayment of its non-revolving term loan facility (the "Loan Facility") with Tallinn Capital Mezzanine Limited Partnership ("Tallinn"). Tallinn has agreed to waive monthly net sales production minimum requirement and minimum current ratio requirements which the Company had been in default of until September 30, 2013. Furthermore, subject to the debentures proposed to be offered pursuant to the Company's recently announced proposed short form prospectus offering (the "Offering") being subordinated and postponed to the Loan Facility on terms acceptable to Tallinn, the successful completion of the Offering and the Company not otherwise being in default under the Loan Facility, Tallinn has also agreed to waive requirements to repay the Loan Facility from proceeds of the Offering beyond the first $2 million of the principal amount owing under the Loan Facility on the earlier of September 30, 2013 or the closing of the Offering.

This article is for information and discussion purposes only and does not form a recommendation to invest or otherwise. The value of an investment may fall. The investments referred to in this article may not be suitable for all investors, and if in doubt, an investor should seek advice from a qualified investment adviser. More

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MIT researchers reveal how the brain keeps eyes on the prize

MIT researchers reveal how the brain keeps eyes on the prize [ Back to EurekAlert! ] Public release date: 4-Aug-2013
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Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology

Researchers reveal how the brain remains focused on long-term goals

Cambridge-- As anyone who has traveled with young children knows, maintaining focus on distant goals can be a challenge. A new study from MIT suggests how the brain achieves this task, and indicates that the neurotransmitter dopamine may signal the value of long-term rewards. The findings may also explain why patients with Parkinson's disease in which dopamine signaling is impaired often have difficulty in sustaining motivation to finish tasks.

The work is described this week in the journal Nature.

Previous studies have linked dopamine to rewards, and have shown that dopamine neurons show brief bursts of activity when animals receive an unexpected reward. These dopamine signals are believed to be important for reinforcement learning, the process by which an animal learns to perform actions that lead to reward.

Taking the long view

In most studies, that reward has been delivered within a few seconds. In real life, though, gratification is not always immediate: Animals must often travel in search of food, and must maintain motivation for a distant goal while also responding to more immediate cues. The same is true for humans: A driver on a long road trip must remain focused on reaching a final destination while also reacting to traffic, stopping for snacks, and entertaining children in the back seat.

The MIT team, led by Institute Professor Ann Graybiel who is also an investigator at MIT's McGovern Institute for Brain Research decided to study how dopamine changes during a maze task approximating work for delayed gratification. The researchers trained rats to navigate a maze to reach a reward. During each trial a rat would hear a tone instructing it to turn either right or left at an intersection to find a chocolate milk reward.

Rather than simply measuring the activity of dopamine-containing neurons, the MIT researchers wanted to measure how much dopamine was released in the striatum, a brain structure known to be important in reinforcement learning. They teamed up with Paul Phillips of the University of Washington, who has developed a technology called fast-scan cyclic voltammetry (FSCV) in which tiny, implanted, carbon-fiber electrodes allow continuous measurements of dopamine concentration based on its electrochemical fingerprint.

"We adapted the FSCV method so that we could measure dopamine at up to four different sites in the brain simultaneously, as animals moved freely through the maze," explains first author Mark Howe, a former graduate student with Graybiel who is now a postdoc in the Department of Neurobiology at Northwestern University. "Each probe measures the concentration of extracellular dopamine within a tiny volume of brain tissue, and probably reflects the activity of thousands of nerve terminals."

Gradual increase in dopamine

From previous work, the researchers expected that they might see pulses of dopamine released at different times in the trial, "but in fact we found something much more surprising," Graybiel says: The level of dopamine increased steadily throughout each trial, peaking as the animal approached its goal as if in anticipation of a reward.

The rats' behavior varied from trial to trial some runs were faster than others, and sometimes the animals would stop briefly but the dopamine signal did not vary with running speed or trial duration. Nor did it depend on the probability of getting a reward, something that had been suggested by previous studies.

"Instead, the dopamine signal seems to reflect how far away the rat is from its goal," Graybiel explains. "The closer it gets, the stronger the signal becomes." The researchers also found that the size of the signal was related to the size of the expected reward: When rats were trained to anticipate a larger gulp of chocolate milk, the dopamine signal rose more steeply to a higher final concentration.

In some trials the T-shaped maze was extended to a more complex shape, requiring animals to run further and to make extra turns before reaching a reward. During these trials, the dopamine signal ramped up more gradually, eventually reaching the same level as in the shorter maze. "It's as if the animal were adjusting its expectations, knowing that it had further to go," Graybiel says.

An 'internal guidance system'

"This means that dopamine levels could be used to help an animal make choices on the way to the goal and to estimate the distance to the goal," says Terrence Sejnowski of the Salk Institute, a computational neuroscientist who is familiar with the findings but who was not involved with the study. "This 'internal guidance system' could also be useful for humans, who also have to make choices along the way to what may be a distant goal."

One question that Graybiel hopes to examine in future research is how the signal arises within the brain. Rats and other animals form cognitive maps of their spatial environment, with so-called "place cells" that are active when the animal is in a specific location. "As our rats run the maze repeatedly," she says, "we suspect they learn to associate each point in the maze with its distance from the reward that they experienced on previous runs."

As for the relevance of this research to humans, Graybiel says, "I'd be shocked if something similar were not happening in our own brains." It's known that Parkinson's patients, in whom dopamine signaling is impaired, often appear to be apathetic, and have difficulty in sustaining motivation to complete a long task. "Maybe that's because they can't produce this slow ramping dopamine signal," Graybiel says.

###

Patrick Tierney at MIT and Stefan Sandberg at the University of Washington also contributed to the study, which was funded by the National Institutes of Health, the National Parkinson Foundation, the CHDI Foundation, the Sydney family and Mark Gorenberg.

Written by The McGovern Institute


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


MIT researchers reveal how the brain keeps eyes on the prize [ Back to EurekAlert! ] Public release date: 4-Aug-2013
[ | E-mail | Share Share ]

Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology

Researchers reveal how the brain remains focused on long-term goals

Cambridge-- As anyone who has traveled with young children knows, maintaining focus on distant goals can be a challenge. A new study from MIT suggests how the brain achieves this task, and indicates that the neurotransmitter dopamine may signal the value of long-term rewards. The findings may also explain why patients with Parkinson's disease in which dopamine signaling is impaired often have difficulty in sustaining motivation to finish tasks.

The work is described this week in the journal Nature.

Previous studies have linked dopamine to rewards, and have shown that dopamine neurons show brief bursts of activity when animals receive an unexpected reward. These dopamine signals are believed to be important for reinforcement learning, the process by which an animal learns to perform actions that lead to reward.

Taking the long view

In most studies, that reward has been delivered within a few seconds. In real life, though, gratification is not always immediate: Animals must often travel in search of food, and must maintain motivation for a distant goal while also responding to more immediate cues. The same is true for humans: A driver on a long road trip must remain focused on reaching a final destination while also reacting to traffic, stopping for snacks, and entertaining children in the back seat.

The MIT team, led by Institute Professor Ann Graybiel who is also an investigator at MIT's McGovern Institute for Brain Research decided to study how dopamine changes during a maze task approximating work for delayed gratification. The researchers trained rats to navigate a maze to reach a reward. During each trial a rat would hear a tone instructing it to turn either right or left at an intersection to find a chocolate milk reward.

Rather than simply measuring the activity of dopamine-containing neurons, the MIT researchers wanted to measure how much dopamine was released in the striatum, a brain structure known to be important in reinforcement learning. They teamed up with Paul Phillips of the University of Washington, who has developed a technology called fast-scan cyclic voltammetry (FSCV) in which tiny, implanted, carbon-fiber electrodes allow continuous measurements of dopamine concentration based on its electrochemical fingerprint.

"We adapted the FSCV method so that we could measure dopamine at up to four different sites in the brain simultaneously, as animals moved freely through the maze," explains first author Mark Howe, a former graduate student with Graybiel who is now a postdoc in the Department of Neurobiology at Northwestern University. "Each probe measures the concentration of extracellular dopamine within a tiny volume of brain tissue, and probably reflects the activity of thousands of nerve terminals."

Gradual increase in dopamine

From previous work, the researchers expected that they might see pulses of dopamine released at different times in the trial, "but in fact we found something much more surprising," Graybiel says: The level of dopamine increased steadily throughout each trial, peaking as the animal approached its goal as if in anticipation of a reward.

The rats' behavior varied from trial to trial some runs were faster than others, and sometimes the animals would stop briefly but the dopamine signal did not vary with running speed or trial duration. Nor did it depend on the probability of getting a reward, something that had been suggested by previous studies.

"Instead, the dopamine signal seems to reflect how far away the rat is from its goal," Graybiel explains. "The closer it gets, the stronger the signal becomes." The researchers also found that the size of the signal was related to the size of the expected reward: When rats were trained to anticipate a larger gulp of chocolate milk, the dopamine signal rose more steeply to a higher final concentration.

In some trials the T-shaped maze was extended to a more complex shape, requiring animals to run further and to make extra turns before reaching a reward. During these trials, the dopamine signal ramped up more gradually, eventually reaching the same level as in the shorter maze. "It's as if the animal were adjusting its expectations, knowing that it had further to go," Graybiel says.

An 'internal guidance system'

"This means that dopamine levels could be used to help an animal make choices on the way to the goal and to estimate the distance to the goal," says Terrence Sejnowski of the Salk Institute, a computational neuroscientist who is familiar with the findings but who was not involved with the study. "This 'internal guidance system' could also be useful for humans, who also have to make choices along the way to what may be a distant goal."

One question that Graybiel hopes to examine in future research is how the signal arises within the brain. Rats and other animals form cognitive maps of their spatial environment, with so-called "place cells" that are active when the animal is in a specific location. "As our rats run the maze repeatedly," she says, "we suspect they learn to associate each point in the maze with its distance from the reward that they experienced on previous runs."

As for the relevance of this research to humans, Graybiel says, "I'd be shocked if something similar were not happening in our own brains." It's known that Parkinson's patients, in whom dopamine signaling is impaired, often appear to be apathetic, and have difficulty in sustaining motivation to complete a long task. "Maybe that's because they can't produce this slow ramping dopamine signal," Graybiel says.

###

Patrick Tierney at MIT and Stefan Sandberg at the University of Washington also contributed to the study, which was funded by the National Institutes of Health, the National Parkinson Foundation, the CHDI Foundation, the Sydney family and Mark Gorenberg.

Written by The McGovern Institute


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-08/miot-mrr080213.php

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From soybeans to baseball, Henry has had success

Boston Red Sox majority owner John Henry watches a baseball game between the Red Sox and Arizona Diamondbacks during the second inning at Fenway Park in Boston, Friday, Aug. 2, 2013. (AP Photo/Charles Krupa)

Boston Red Sox majority owner John Henry watches a baseball game between the Red Sox and Arizona Diamondbacks during the second inning at Fenway Park in Boston, Friday, Aug. 2, 2013. (AP Photo/Charles Krupa)

(AP) ? John W. Henry took a backward ballclub in a dilapidated park and transformed it into a two-time World Series champion that is one of baseball's model franchises.

As the owner of The Boston Globe, he will try to turn around a newspaper that ? like many other major metro dailies ? is shedding staff, subscribers and advertisers as it makes the transition into the Internet age.

Henry agreed to buy the Globe along with the Worcester Telegram & Gazette and the Boston Metro for $70 million, a fraction of the $1.1 billion The New York Times Co. paid 20 years ago. Henry apparently made this deal without his Red Sox partners, though he said in a statement that more information will soon be available "concerning those joining me in this community commitment and effort."

The son of southern Illinois soybean farmers now worth an estimated $1.5 billion, Henry was a minority owner of the New York Yankees and the sole owner of the Florida Marlins when he led a group that bought the Red Sox for $660 million in 2002. (The original group included The New York Times, which sold the last of its 17.5 percent ownership last year.)

They soon set out to preserve Fenway Park while taking a wrecking ball to most everything else that had mired the franchise in failure for more than eight decades.

Henry, who made his money by taking a mathematical approach to the commodities markets, brought a similar method to the baseball diamond, hiring the statistically savvy Theo Epstein, then 28 years-old, as the youngest general manager in baseball history. They hired statistical pioneer Bill James as a consultant, putting the Red Sox at the forefront of the revolution that had just begun to take hold in front offices long dominated by old-time and hidebound scouting types.

But, perhaps more importantly, the new owners turned what had long been a stagnant family business into a revenue spigot.

They took NESN, which had been almost exclusively an outlet for Red Sox and Boston Bruins games, into a full-fledged sports network. (Not every effort ? like the sports-themed dating show "Sox Appeal" ? was a success.) And they spent more than $285 million turning the once-doomed Fenway Park into a modern ? well, as modern as a 100-year-old ballpark can be, anyway ? sporting venue.

With seats above the Green Monster and a roof deck in right field, a high-tech scoreboard and new concourses and concessions, Fenway sold out 820 consecutive games ? by official count, anyway ? the longest such streak in professional sports history. Thousands more file through the turnstiles 12 months a year, paying up to $16 just to see the park when it is empty.

Though fans sometimes chafed at the team's new businesslike approach, the initiatives helped pay for a player payroll that grew from $75.5 million in 2000 to more than $130 million by 2004. That year, the Red Sox won the World Series for the first time in 86 years, ending one of the longest title droughts in sports.

They won again three years later.

Henry was also a different kind of owner than Bostonians had grown accustomed to.

While most owners of the local franchises had treated their teams like family fiefdoms or corporate cash registers ? or both ? Henry engaged with fans, chatting with them on Internet message boards (he would also became an early adopter on Twitter). He spent less time in his luxury box and more in his dugout-side seats, and was once seen running the bases on the Fenway diamond with the woman who is now his wife.

And Henry kept looking beyond baseball.

Through a sister company, the Red Sox owners bought into NASCAR as co-owners of Roush Fenway Racing; soccer, by purchasing the Liverpool FC of the English Premier League; and basketball, through a sponsorship deal with LeBron James. Their business offshoot, known as New England Sports Ventures, has also dabbled in marketing for college sports and professional golf.

In buying a newspaper, Henry enters an industry in turmoil and joins a progression of publishers who have tried to figure out how to balance the free-flowing information of the internet with the costs of quality journalism.

While providing no clues, Henry vowed to try.

"The Boston Globe's award-winning journalism as well as its rich history and tradition of excellence have established it as one of the most well-respected media companies in the country," he said in his statement. "This is a thriving, dynamic region that needs a strong, sustainable Boston Globe playing an integral role in the community's long-term future."

___

Follow Jimmy Golen on Twitter at http://www.twitter.com/jgolen.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-08-03-Boston%20Globe-Henry/id-3f31d85c0e3f401eafec2ac0dd4fe85e

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Sunday, August 4, 2013

SMU Mustangs NCAA Football Gambling Odds & Predictions

June Jones is an established coach and when he left Hawaii for SMU big things were expected. After a disastrous 1-11 start the Mustangs have played .500 or better each season since, participating in bowl games the last 4 seasons ? winning 3.

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SMU Mustangs
Coach: June Jones
2012 Record: 7-6
Odds of winning BCS Championship: +2000 (Field)
Odds From Betonline

Now they are leaving Conference USA for the experiment that is the American Athletic Conference. A stellar introductory season is not expected given the state of the program though.

As Jones is an ?offense guy? Hawaii and SMU have generally been very good on that side of the ball especially throwing it. Last year they dropped off dramatically in that area not even ranking in the top half of teams nationally in that category.

The defense actually wound up carrying them, especially in their bowl victory over a good Fresno State team, but you can bet Jones will be working hard to get things back on track offensively this season.

It just might be a struggle even for a noted offensive mind like him.

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Senior QB Garrett Gilbert is a classic transfer story. He wasn?t going to be the guy at Texas so he transferred to a place where he could play and improve his NFL stock after being highly touted as a recruit. SMU seemed like a great fit for him but last year he just wasn?t as efficient throwing the ball as you would expect from a QB in Jones? system.

He completed just 53% of his passes with only a 15/15 TD/INT ratio. If he is not better than the Mustangs are sunk because the quality of defenses in their new league should be higher than what they are used to.

It would be helpful if the Mustangs had a solid ground game but that seems unlikely given that Zach Line(another transfer), the second leading rusher in program history (behind Eric Dickerson) has graduated.

Also not helping is that the line returns just 2 starters . They are trying to replace Line with another Longhorns castoff in RB Traylon Shead who played a year in junior college before matriculating to SMU.

Shead has looked good on the practice field but will need to produce in games in the fall.

Surprise, last year SMU had the third best scoring defense in C-USA and was #1 in the conference against the run.

On the flip side they were #11/#109 against the pass which is why it is a bit of a mixed bag that all the starters returning from the unit are in the back seven. Teams from the former Big East are generally pretty balanced on offense so SMU will have to find some linemen that can stuff the run and hope that experience will help a secondary that was torched at times last season.

C-USA was a passing league so those numbers could be a little inflated ? maybe.

2013-14 Record Projection: 3-9

Unfortunately I think this is going to be a down year for SMU.

The defense is likely to take a big step back this season and I am not sure the offense is ready to pick up the slack. QB Gilbert would need to have a super efficient season and I am just not sure he has it in him.

He does have a couple of starting wideouts returning but it might not be enough if the ground game doesn?t produce. Also not helping matters is a tough schedule. The non-conference is probably a 1-3 deal with games against Texas Tech and @Texas A&M and @TCU (plus a visit by Montana State). Even if they can split those there are at most three victories in their AAC slate as they have some tough home and road games and will be facing some unfamiliar opponents.

It doesn?t look very promising right now and this is probably a team to forget when it comes to wagering.

2013 Mustangs Schedule

AUG 30 ? Texas Tech
SEP 7 ? Montana State
SEP 21 ? @Texas A&M
SEP 28 ? @TCU
OCT 5 ? Rutgers
OCT 19 ? @Memphis
OCT 26 ? Temple
NOV 9 ? @Cincinnati
NOV 16 ? Connecticut
NOV 23 ? @South Florida
NOV 29 ? @Houston
DEC 7 ? UCF

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Source: http://www.capperspicks.com/blog/ncaa-football/smu-mustangs-predictions-2013-betting-lines-schedule-3813/

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In Nebraska, university and school districts build formula for better math education



Discovery
In Nebraska, university and school districts build formula for better math education

Support from local foundations spurs growth at an innovative NSF-funded partnership working to close the math achievement gap

August 2, 2013

It took Paula Jakopovic more than a decade of public education before she experienced her "spark:" before math "came alive," before she learned to explore and collaborate and discuss the subject oft-maligned by students and teachers alike.

But once that math spark hit, Jakopovic had one thought. "I want to do that. I want to do that for kids." And even: "I want to do that for teachers someday."

As an elementary mathematics coach in Omaha Public Schools, Jakopovic now works to trigger similar sparks for her colleagues and students. Her job--and the lessons leading to it--stem from an innovative partnership between the University of Nebraska-Lincoln (UNL) and some of the state's largest school districts.

Long funded by the National Science Foundation (NSF), the partnership encompasses three projects of NSF's Math and Science Partnership (MSP) program and the Robert Noyce Teacher Scholarship program: NebraskaMATH, Math in the Middle and NebraskaNOYCE. Together, they have allowed hundreds of Nebraska teachers to earn advanced degrees in mathematics education, supported dozens more as they work in high-needs schools and prompted the growth of a cadre of master teachers. The partnership is built on the idea that better math teachers make better math students.

A recent funding boost could help the partnership produce more of both. In July, Omaha-based Lozier Foundation and the Sherwood Foundation announced a $5.5 million grant to support a three-year NebraskaMATH Omaha Public Schools Teacher Leader Academy. It will allow more than 200 teachers in the Omaha district to take graduate coursework in mathematics education. Omaha is Nebraska's largest district. More than 70 percent of the students are ethnic minorities and receive free and reduced lunch.

The grant "gives us a real opportunity to make a big difference," said Jim Lewis, director of UNL's Center for Science, Mathematics and Computer Education, which houses NebraskaMATH and the other initiatives. "I'm just honored that there are public-minded citizens in Omaha willing to make this major commitment," he said. "I think that NSF funding made it possible to develop and refine these programs...to do the research that offers reasons to believe that these things make a difference, in the lives of students as well as teachers."

A mathematician by training, Lewis began working with his education faculty colleagues nearly a decade ago, crafting Math in the Middle: a master's degree program for middle school mathematics teachers in Lincoln and rural Nebraska districts. Over the years, that project evolved and intertwined with other NSF grants. Now, UNL and partner schools work together on K-12 math teacher development, plus support for science, technology, engineering and math majors and professionals to become secondary math teachers in high-needs schools.

"We not only want to provide professional development and graduate education," Lewis said. "We want to take the very best and give them opportunities to be a part of the instructional faculty," creating talented teachers who become leaders in their schools and share knowledge with others.

This is the approach Jakopovic now takes in her own school. The Math in the Middle classes she took were intense and sometimes frustrating, she said, but they helped her become a better teacher.

"It gave me a lot of perspective on kids that struggle through math."

NebraskaMATH and its partner initiatives have crafted a "wonderful partnership," said Joan Prival, program director for the MSP and Noyce programs at NSF. By linking the university and school districts, as well as new math teachers and seasoned ones, "They are building this strong and enduring community--mathematics teachers, school administrators, and higher education mathematics and mathematics education faculty--focused on positive experiences and outcomes for students."

Measuring the effectiveness of the projects is ongoing. But in Lincoln, where multiple teachers have now received advanced degrees, "It's changing the conversation in elementary schools," Lewis said.

"I think this has grown in ways that I didn't anticipate," said Ruth Heaton, a UNL professor of teaching, learning and teacher education who has worked with Lewis on these projects since 2004. Heaton expected the program to focus simply on people becoming better classroom teachers. Instead, she found teachers eager not only to learn, but also to work towards a master's degree. Or beyond: Half of the original class of Noyce scholars are pursuing doctorates.

Yet what makes Heaton proudest is something far less tangible. "I think the piece that I feel best about is the way in which we've helped teachers...see what they're capable of. We've helped teachers see that they can reason and think about mathematics. And we've done the same thing for children."

Investigators
Ira?Papick
Ruth?Heaton
Wendy?Smith
David?Fowler
Thomas?McGowan
Carolyn?Edwards
Stephen?Swidler
Barbara?Jacobson
Douglas?Kauffman
W. J. 'Jim'?Lewis

Related Institutions/Organizations
University of Nebraska-Lincoln

Locations
Nebraska

Related Programs
Math and Science Partnership
Robert Noyce Teacher Scholarship Program

Related Awards
#0831835?Nebraska Math
#0412502?Math in the Middle Institute Partnership
#1035268?NebraskaNOYCE: NSF Mathematics Teaching and Master Teaching Fellows Program

Total Grants
$18,135,407

Related Websites
NebraskaMATH: http://scimath.unl.edu/nebraskamath/index.php

Source: http://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=128712&WT.mc_id=USNSF_1

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Saturday, August 3, 2013

Guest Post: Getting Started with Strength Training | Fitness & Feta

Hi to all the Fitness and Feta fanatics out there!? I am a loyal F and F reader from its inception and one of Athena?s good gym friends, Ashley.

Ashley

As a disclaimer, I have no formal training in anything fitness related (I am a Speech-Language Pathologist according to my degrees), but I have made fitness a regular part of my life since around 2005.? However, I didn?t get started in my absolute FAVORITE part of fitness, strength training, until about 2008.? That year I was a senior in college at UMass Amherst and looking to take some ?fun? classes for credit.? I found a strength training class in the Five-College Consortium at Hampshire College (right up the street) and signed right up! (side note: I also took SCUBA for credit that year ? man do I miss being in college!).? In that class I learned about many different strength machines as well as how to properly use free weights, and I have been using them ever since!? More recently (since around April), I decided I really wanted to challenge myself and go for much heavier weights with bigger, full body movements (deadlifts, squats, pull ups, etc).? This is the journey I will be discussing today?

I have never had any personal training before, but I decided that if I was going to lift heavier, I wanted to make sure my form was correct and I wasn?t going to injure myself.? I decided that getting some proper coaching would be worth the money, at least initially, until I got my form down.? I decided to find a Strength and Conditioning Coach rather than a Personal Trainer.? This link gives a pretty good breakdown of one versus the other.? While they are very similar, I decided a Strength and Conditioning Coach would be better for me since I wanted to focus more on strength training, movement patterns, and injury prevention.? I was referred by a friend to Coach Tad Sayce at Sayco Performance, and I have been seeing him once a week since April.? Tad has helped me improve my movement patterns, increase my flexibility, and increase my overall strength.? He has written me programs to follow while at the facility with him as well as programs to follow when I am training without him during the rest of the week.? Whenever I have pain in certain areas or something doesn?t feel right, he helps me figure out what?s causing the problem, fix it, and re-writes my program if necessary.? These are a few of the exercises I?ve been working on consistently with him:

Deadlift

I have done a few variations of deadlifts ? trap bar deadlifts, single leg deadlifts, and sumo deadlifts (pictured below).? Deadlifts work a bunch of muscles, but mostly the hamstrings and glutes.? I loooooove deadlifts! They are dangerous because if not done properly, you could hurt your lower back (and probably other areas as well).

Ashley Deadlift

Chin Ups

Usually chin-ups are done with an underhand grip, while pull-ups are done with an overhand grip.? In the picture below, I am doing them with a neutral grip, which is kind of in-between, but chin-ups are generally the easier of the two exercises, so that?s what I am starting with.? Chin-ups are a great upper body workout because they work your biceps, shoulders, back, and core.? Chin-ups have been the bane of my existence for a while because it is an exercise that I simply can?t do unassisted YET.? Strength ability, like anything else, varies widely from person to person and my good friend Addie said to me a few weeks ago ?You encouraged me to try doing chin ups, but I can only do a few.?? Well, I have been working my butt off on them since April and I can?t do any yet!? Pictured below, I am using a resistance band, so I will continue working my way to less resistance until I don?t need anything!? You bet your tushy I will brag for a while on Facebook when that happens, complete with picture and video.

Ashley Chin Up

Squats

With Tad, I have been working on goblet squats and front squats (pictured below).? Squats are a great full body exercise, but they mainly work the quads.? I had never done front squats before, and I have learned a lot about technique and squat movement from Tad.? In the picture, you?ll see that I have a wider stance and my toes are pointing outwards a bit.? Because of my hip movement patterns, this allows me to get more depth (squat lower).? I also learned that I was leaning a bit too far forward in my squats, so you?ll see in the picture that my back is pretty straight.

Ashley Squat

Push Ups

I had always done push-ups on the ground, but I realized I was ?cheating? and not going as far down as I should, so I have been doing incline push ups with Tad to improve my form.? Push-ups are another great upper body exercise because they work your core, chest, back, shoulders, and triceps.? If you elevate your hand placement (as seen in my picture) on a barbell, bench, step, etc, it makes the push-up easier.? Placing your hands on the ground would make it a regular push-up, and elevating your feet would make it harder. Additionally, you can change your hand placement to work different muscles (wider, narrower, etc).

Ashley Pushup

I enjoy strength training because I would rather focus on adding more weight to my barbells than the number on the scale.? Also, there is no better feeling than being the bad-ass chick with all the men in the weight room.

Amber Rogers at GoKaleo.com just did a great 3-part series on Taming the Weight Room if you want more information on how to get started with strength training.? I highly recommend hiring a Personal Trainer or Strength and Conditioning Coach to show you the ropes and proper form, but I understand that?s not financially reasonable for a lot of people.? I would recommend doing some more reading on the exercises you want to start and start with very light weight (or just bodyweight!) until you really get the form down!

Good luck and don?t give up!

Thank you, Ashley, for your guest post!? You know I always love hearing about your new strength training adventures.

Let?s chat ? Do you strength train with heavier weight?? Have you ever used a personal trainer or a strength and conditioning coach before?

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Source: http://fitnessandfeta.com/2013/08/02/guest-post-getting-started-with-strength-training/

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OUYA offers $13.37 store credit as mea culpa to Kickstarter supporters

OUYA offers $1337 store credit as mea culpa to Kickstarter supporters

If you were a die-hard Kickstarter supporter of OUYA, you might have had your feelings hurt to know the Android console was actually available for retail before you got yours in the mail. It looks like OUYA founder and CEO Julie Uhrman is certainly aware of that (along with a few other teething problems) as she has just sent out an email with the above image, offering all Kickstarter supporters a $13.37 credit to its Discover store. While that may not solve all of OUYA's issues, at least early adopters will feel better about it after a hearty round of You Don't Know Jack.

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Source: http://www.engadget.com/2013/08/02/ouya-store-credit-kickstarter-supporters/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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U.S. jobs data may show strength, prompt stimulus end

By Richard Hubbard

LONDON (Reuters) - Investors positioned for a strong U.S. jobs report on Friday, balancing the likelihood it will confirm the economy is recovering with wariness it might prompt the Federal Reserve to end its stimulus earlier.

Gold headed for its biggest weekly loss in a month and German bond yields rose. World stocks headed towards two-month highs and Brent oil reached above $110 a barrel for the first time since April.

Italian bonds meanwhile braved growing political uncertainty after Italy's top court upheld a jail sentence against former premier Silvio Berlusconi that could throw the country's coalition into crisis.

Italian government bond yields were down 3 basis points at 4.34 percent.

The main market focus was on July's U.S. payrolls report, which is likely to fuel optimism that a recovery is taking hold.

But coming just after Fed Chairman Ben Bernanke tried to ease concerns about an imminent tapering of its money-printing stimulus, a strong number could reignite some market volatility.

The prospect of an end to stimulus - which has pumped billions of dollars into world markets - has already battered some assets, notably in emerging markets.

"The data in the U.S. is picking up appreciably at the moment. It's all pointing to a better (jobs) number today and bond markets should be scared," said William Hobbs, head of equity strategy at Barclays Wealth.

The payrolls report is forecast to show an increase of 184,000 in jobs outside the farm sector last month and the jobless rate dropping to 7.5 percent from 7.6 percent, according to a Reuters poll.

The unemployment rate is closely monitored by the Fed as it gauges when to cut back its $85 billion a month bond-buying program.

STIMULUS

The prospect of an end to U.S. stimulus pushed German bond yields up by 3 basis points to 1.7 percent as they kept pace with a rise in U.S. Treasury bond yields, which are now trading near two-year highs.

The dollar extended its gains versus the yen by 0.2 percent to 99.75 yen having surged about 1.7 percent on Thursday for its biggest one-day percentage gain in about four months. The dollar index <.dxy> was up 0.1 percent at 82.413.

The dollar's broad strength weighed on gold which slipped to a two-week low and below a key technical level near $1,300, on its way to the its worst weekly performance in a month.

In the equity markets, which have welcomed the signs of economic recovery, European shares were on course to reach highs not seen for more than two months, with the broad FTSE Eurofirst 300 index <.fteu3> up 0.15 percent in early trade.

MSCI's world equity index <.miwd00000pus> was up 0.2 percent, closing in on its highest level since late May. U.S. stock futures pointed to further gains later in the day.

(Editing by Jeremy Gaunt)

Source: http://news.yahoo.com/asian-shares-buoyed-u-data-accommodative-central-banks-032636031.html

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Former Cincinnati Reds player coach Dave Collins has been hired as head baseball coach for St Henry High School in Erlanger ...

SbB LIVE FROM LA (Aug 2, 2013 @ 5:14pm ET)

6:00 PM: KTVK reports that Megan Welter, an Arizona Cardinals cheerleader who had served with the U.S. Army in Iraq, was arrested on assault charges on July 20 in an incident involving her boyfriend.

5:45 PM: The Spokane Spokesman Review reports former NBA player Craig Ehlo had lit a pile of clothes on fire and was behind held down by family members who were afraid Ehlo would jump into the fire. Ehlo was arrested Thursday on domestic violence & reckless burning charges.

5:30 PM: UConn women's basketball player Stefanie Dolson said she meant no disrespect when she gave President Obama bunny ears while posing for a photo at the White House Wednesday: "President Obama's a lighthearted guy .... even during his speech he was joking around."

5:15 PM: Baltimore Ravens cornerback Asa Jackson has been suspended eight games by the NFL for violating the league's PED policy.

5:00 PM: Former Princeton football player & 1951 Heisman Trophy winner Dick Kazmaier died Thursday at the age of 82. Kazmaier was the last Ivy League player to win the Heisman.

4:45 PM: Peter Gammons reports that the New York Times Corporation has chosen Boston Red Sox owner John Henry as the new owner of the Boston Globe newspaper.

4:30 PM: Suspended Milwaukee Brewers player Ryan Braun has reportedly been dropped by Nike as an endorser for the shoe company.

4:15 PM: The Oakland Raiders announce they have signed kicker Sebastian Janikowski to a four-year contract extension.

4:00 PM: In an interview with WEEI radio Friday, former Boston Red Sox & current Arizona Diamondbacks outfielder Cody Ross said the Sox "lied to my face" during contract talks last season. Arizona is visiting Fenway Park this weekend.

3:45 PM: Former Cincinnati Reds player & coach Dave Collins has been hired as head baseball coach for St. Henry High School in Erlanger, Kentucky. Collins had previously served as basketball coach for high school teams in Ohio & Michigan.

3:30 PM: A 59-year-old man was arrested for running onto the field at the New Orleans Saints' training camp on Friday. David Mobley was charged with remaining after forbidden, resisting arrest & battery on a police officer.

3:15 PM: In a video for the Illinois Lottery, Patrick Sharp surprised a family of Chicago Blackhawks fans by dressing as a waiter & bringing them room service during last weekend's Blackhawks Convention at the Chicago Hilton.

3:00 PM: Western Kentucky football coach Bobby Petrino said on Wednesday that secondary coach Mike Cassity is "doing well" after dealing with cancer: "He has beat the battle and will get better and better. He is a great coach and tremendous recruiter, and he is getting better."

2:45 PM: Roger Federer announced he will not play in next week's Rogers Cup in Montreal due to ongoing back issues. Federer has lost in early rounds of three straight tournaments including Wimbledon.

2:30 PM: Detroit Tigers scout Mike Russell reportedly paid the funeral expenses of James Van Horn, a homeless Tigers fan who was struck and killed by a hit & run driver last Saturday. Van Horn was often seen outside Comerica Park chanting to fans, "Eat 'em up Tigers, eat 'em up!"

Source: http://www.sportsbybrooks.com/sbblive?eid=54704

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Friday, August 2, 2013

The View from 22 ? Twitter abuse wars, Theresa vs Boris and Egypt?s Arab winter

Will online abuse and trolling ever be stopped? On this week?s View from 22 podcast, Hugo Rifkind discusses his Spectator column on the subject with Helen Lewis of the New Statesman. They ask if trolling has got better or worse? What, if anything, can or should be done about ?morons? who mindlessly attack people? And should politicians ? like Stella Creasy ? be influencing the moderation policies of social networks like Twitter?

James Forsyth and Toby Young discuss the next Tory leadership battle: Theresa May vs. Boris Johnson. James reports that these two top Tories are jostling to succeed David Cameron, even though the PM is expected to be in situ after 2015: Boris isn?t even going to stand in the 2015 election. Who is most likely to be successful? And how might the EU referendum help Boris position himself to succeed Cameron?

Plus, the Telegraph?s Con Coughlin and Douglas Murray explain why Egypt?s deposed Muslim Brotherhood should have learnt from its own past and looked to Colonel Nasser on how to run the country.

You can subscribe to the View from 22 through iTunes and have it delivered to your computer every week, or you can use the embedded player below:

The View from 22 ? 1 August 2013. Length: 36:43

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Tags: Boris Johnson, Muslim Brotherhood, New Statesman, Podcast, The View from 22, Theresa May, Twitter

Subscribe with our offer of the summer: three months? print and digital subscription to the Spectator ? including our apps for?iPad, iPhone and Kindle Fire ? for just ?12. Click here to join us.

Source: http://blogs.spectator.co.uk/coffeehouse/2013/08/the-view-from-22-twitter-abuse-wars-theresa-vs-boris-and-egypts-arab-winter/?utm_source=rss&utm_medium=rss&utm_campaign=the-view-from-22-twitter-abuse-wars-theresa-vs-boris-and-egypts-arab-winter

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NEW HAVEN WOMEN'S BASKETBALL: Former star Ty Grace returns as coach

New Haven women's basketball coach Ty Grace. (Photo courtesy of New Haven Athletics)

WEST HAVEN ? There?s one thing certain about Ty Grace in her new role as women?s basketball coach at the University of New Haven: She isn?t going to be intimidated by the competition.

That?s not to say that battling the likes of Northeast-10 powerhouses like Bentley isn?t difficult, but Grace has spent the last four years as an assistant at Seton Hall.

?I?ve been in the Big East,? Grace said. ?We?ve played UConn and Notre Dame, the best teams in the country.?

Grace replaces Jessica Smith, who left to take an assistant?s role under first-year coach Jessica Mannetti at Sacred Heart University. Smith led the Chargers to a 14-13 mark last season, a staunch improvement from the 3-23 mark the prior season.

?The foundation is here,? Grace said. ?Now we have to build on it.?

It is a homecoming for Grace, who graduated from New Haven in 1999 and registered over 1,000 points and 1,000 rebounds in her stellar career.

?I?m just so excited to be back,? Grace said. ?It?s going to be so much fun to play in alumni games and go to homecoming and see all my old friends. I haven?t been able to do that in so long because of my other commitments.?

Grace has 13 years of Division I coaching experience and served as a head coach at Ramapo College in New Jersey from 2004-06. She most recently served under current Connecticut Sun coach and Hall of Famer Anne Donovan while at Seton Hall as the top assistant and recruiting coordinator.

?Without a doubt (Donovan) is one of the best coaches I?ve ever worked for,? Grace said. ?I learned so much from her. We were building a great program there and I learned how to build from her. She?s also just a great person.?

Grace was instrumental in assembling recruiting classes ranked as high as 25th in Division I, including the signing of two McDonald?s All-America nominees. Continued...

Grace was Donovan?s top recruiter while at Seton Hall and hopes to hone that skill at New Haven. For now, however, she takes over a team with a full roster.

?We had no scholarships (to offer) so I?m just working for the 2014 season,? Grace said. ?To be a great team you have to have great players and I?m hoping that the relationships I?ve built will pay off. I?ve already been out recruiting and getting ready for next season.

?One thing that I?m looking for is great kids, too. I want to have great players, but they have to be great kids.?

The most difficult task that Grace may face is evaluating her current players. Grace not only didn?t recruit them, she?s never seen them play.

?I?ve gotten a chance to talk to each one of them and they?re all excited,? she said. ?Right now I?ve be watching tapes on them. But it will be fine. We?ve got time to work together and build a team.?

Grace said she wasn?t about to put a timetable on making the Chargers a conference contender.

?That?s the goal,? she said. ?New Haven wouldn?t have hired me if they didn?t think that I could do it and I wouldn?t have taken the job if that wasn?t in their plans. It?s going to be a process. I don?t know if it?s going to take four years or so, but we have a high level of expectations.?

Grace is the 16th head coach in program history and was inducted into the New Haven Athletics Hall of Fame in 2010.

Source: http://www.nhregister.com/articles/2013/08/01/sports/doc51fb2aeddfc51325596599.txt

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iPhone 5S to be Powered by Samsung-Made A7 Chips on Release Date?

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Source: www.ibtimes.com --- Wednesday, July 31, 2013
The iPhone 5S to sit on store shelves later this year will have components sourced from Apple?s arch foe, Samsung, despite the former?s moves of gradually easing out the Galaxy maker from its supply chain system. ...

Source: http://www.ibtimes.comhttp:0//www.ibtimes.co.in/articles/496019/20130801/iphone-5s-powered-samsung-made-a7-chips.htm

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Not enough brake fluid blamed for Bangor Fourth of July Parade Death

BANGOR, Maine (NEWS CENTER)-- There was not enough brake fluid in a city owned fire truck, that was the finding of a police collison reconstruction report into the fatal crash in Bangor's Fourth of July Parade that claimed the life of 63 year Wallace Fenlason. Fenlason was driving the antique tractor that was struck from behind by the city's 1930 Mcann Fire Truck.?

It was 86 degrees and sunny at 12:40 p.m.?on the Fourth of July when the crash happened, just as the 1930's era Fire Truck turned from Main Street onto Water Street. Bangor Firefighter Patrick Heathcote was at the wheel of that truck. According to the report, he tried to stop but couldn't.? "Heathcote stated that the brakes failed and the pedal went to the floorboards." the report states. ?"Several witnesses also stated they saw Heathcote "standing on the brakes", yet the fire truck did not stop and struck the tractor."??

The investigator said there were flakes of paint embedded in pedal openings of the floorboard. ? ?"It was apparent that the pedals had been pressed into the floorboard with a great amount of force." the report concluded. ???

The six ton fire truck hit the tractor and then ran over Fenlason, killing him instantly. The accident reconstruction found the crash happened on the steepest point of the parade route and that?the truck's failure to stop was due to an insufficient amount of brake fluid and poor quality brake fluid which introduced air into the brake system.

Water street was not part of the original route. Bangor Police diverted the parade away from a standoff they had with a man in an apartment on Park Street who was firing shots out a window. ?City Attorney Norman Heightmann had no comment about the report and would not comment while the city's insurance company is investigating the claim.

NEWS CENTER

Source: http://www.wcsh6.com/news/local/story.aspx?storyid=251764

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MLB tells union which players it plans to suspend

NEW YORK (AP) ? Major League Baseball has told the union which players it intends to suspend in its drug investigation and which ones will receive lengthier penalties for their roles in the Biogenesis case, two people familiar with the talks told The Associated Press.

The sides are trying to reach as many agreements as possible that would avoid grievance hearings, and talks could push back an announcement until Friday.

The meeting between MLB and the union on Tuesday, first reported by the New York Daily News, signaled the final stretch of talks. MLB hopes to announce the penalties for all players involved at the same time, both people said, speaking on condition of anonymity because no announcements were authorized.

Three-time MVP Alex Rodriguez of the New York Yankees stands to receive the longest suspension. While 50 games is the standard for a first offense, the stiffer penalties for some players are tied to other alleged violations, including not being truthful to MLB investigators.

Three 2013 All-Stars could face bans: Texas outfielder Nelson Cruz, San Diego shortstop Everth Cabrera and Detroit shortstop Jhonny Peralta. In a sign Peralta's suspension might be imminent, the Tigers acquired shortstop Jose Iglesias from Boston on Tuesday night as part of a three-way trade with the Chicago White Sox.

"The frank reality is that I do not know what is going to happen with Jhonny, but with this move, we now feel well protected if there is a long suspension," Tigers general manager David Dombrowski said.

Another 2013 All-Star, Oakland pitcher Bartolo Colon, was suspended last year following a positive testosterone test, as were Toronto outfielder Melky Cabrera and San Diego catcher Yasmani Grandal. They won't receive additional discipline for that violation, the two people said.

Yankees catcher Francisco Cervelli and Seattle catcher Jesus Montero also have been linked in media reports to Biogenesis, a closed Florida anti-aging clinic that was accused by Miami New Times in January of distributing banned performing-enhancing drugs.

Melky Cabrera was the 2012 All-Star game MVP while with San Francisco and Colon won the 2005 AL Cy Young Award with the Los Angeles Angels.

Players who don't reach agreements can ask the players' association to file grievances, which would lead to hearings before arbitrator Fredric Horowitz. Discipline for first offenders under the drug agreement usually is not announced until after the penalty is upheld, but there is an exception when the conduct leading to the discipline already has been made public.

In addition, MLB may try to suspend Rodriguez under its collective bargaining agreement instead of its drug rules, which would lead to the suspension starting before the appeal.

Milwaukee outfielder Ryan Braun was the first player to reach an agreement with MLB. The 2011 NL MVP accepted a season-ending 65-game suspension last week. Braun tested positive for elevated testosterone in October 2011 but a 50-game suspension was overturned the following February by an arbitrator who ruled Braun's urine sample was handled improperly.

Rodriguez faces the harshest penalty. The Yankees expected him to be accused of recruiting other athletes for the clinic, attempting to obstruct MLB's investigation, and not being truthful with MLB in the past when he discussed his relationship with Dr. Anthony Galea, who pleaded guilty two years ago to a federal charge of bringing unapproved drugs into the United States from Canada.

"A-Rod was my teammate in New York. I'm glad he was my teammate," retired pitcher Roger Clemens said Tuesday in Boston, where he was at Fenway Park to mark the 25th anniversary of manager Joe Morgan's team that won the 1988 AL East title.

"I did things to make him feel comfortable. I did that for all of my teammates," Clemens said. "I think I was a pretty solid teammate."

The seven-time Cy Young Award winner was acquitted last year of federal charges he lied to Congress when he said he didn't take steroids or human growth hormone.

Clemens would not give his thoughts on MLB's Biogenesis investigation.

"I've got my own feelings on particular people in MLB, you know, how they approached my situation," he said. "I don't know about it, and I don't care about it, to tell you the truth."

___

AP freelance writer Ken Powtak in Boston contributed to this report.

Source: http://news.yahoo.com/mlb-tells-union-players-plans-suspend-031229010.html

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Thursday, August 1, 2013

HTC One mini passes through the FCC with AT&amp;T-capable LTE

HTC One Mini reaches the FCC with AT&Tcapable LTE

There have been rumors of the HTC One mini coming to AT&T, including a reported press shot from Android Police, but we've seen little in the way of hard evidence. Thankfully, the FCC just gave us Exhibit A: the One Mini has once again shown up at the US agency, this time with support for AT&T-friendly HSPA+ and LTE frequencies. Although there are few surprises in store, the new variant doesn't offer HSPA+ for T-Mobile; HTC isn't likely to repeat the multi-carrier strategy that brought the full-size One to the US. That may disappoint customers on other networks, although if it's any comfort, the FCC appearance hints that the device could reach Americans relatively soon.

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Source: http://www.engadget.com/2013/08/01/htc-one-mini-passes-through-the-fcc-with-att-capable-lte/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Friday, July 26, 2013

U.S. drugmakers cheer 'speed lane' for breakthrough therapies

By Toni Clarke

WASHINGTON (Reuters) - A new regulatory pathway could shave years off the traditional drug approval process in the United States, according to some companies whose drugs have been given "breakthrough therapy" designation by the U.S. Food and Drug Administration.

Speaking at a briefing in Washington to raise awareness of the drug review process, Dr. Jay Siegel, head of global regulatory affairs at Johnson & Johnson, said he expects two years to be knocked off the time it would typically take the FDA to review ibrutinib, the company's experimental cancer drug.

To be granted breakthrough designation, an experimental drug must show early indication of clinical improvement over existing therapies, even if the clinical trial is small. It might apply, for example, to a new type of cancer drug that shows strong early promise.

J&J's ibrutinib, which it is developing with Pharmacyclics Inc, would be the first in a class of oral medicines that block a protein known as Bruton's tyrosine kinase. It is being developed for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and for patients with mantle cell lymphoma, both cancers of the blood.

Dr. Jeffrey Leiden, the chief executive of Vertex Pharmaceuticals Inc, who also spoke at the briefing and whose cystic fibrosis drug Kalydeco was given the designation after approval, said his company's experience working with the FDA was dramatically different from the normal drug approval process.

Under breakthrough designation, he said, "everything is on the table" for discussion in order to move the process along as quickly as possible. Communications that might typically take weeks and months, under the breakthrough pathway take minutes.

"We pick up the phone and talk in real time," Leiden said. "It makes the process immeasurably smoother."

The breakthrough pathway was spearheaded by Friends of Cancer Research, a patient advocacy organization. It received bipartisan support in Congress and was signed into law in July 2012. As of July 12, the FDA had received 67 requests for breakthrough designation. It had granted 24 and denied 18.

Dr. Janet Woodcock, director of the FDA's drugs division, said during the discussion that the breakthrough pathway was designed to accommodate new science, particularly targeted therapies that may work in people with certain genetic mutations. She noted that just because the review process is speeded up there is no guarantee of approval.

In the 1990s, she said, the agency was not seeing drugs whose promise could be detected in early clinical trials.

"We didn't see these therapies in Phase I or II where you said 'bingo,' you've got a likely winner," she said.

Still, there are challenges associated with speeding up a drug's development timeline. For one thing, other nations might not be willing to approve the products based on the FDA's more flexible clinical trial standards under the breakthrough designation.

"Our hope is that foreign regulators will catch up," Siegel said.

Moreover, he said, it is not clear that insurers will pay for drugs if the data do not show improved survival or other clear benefit they are used to seeing when drugs are approved. One task, he said is to figure out "how to bring payors on board."

The panelists did not discuss what happens once a drug reaches the market under the breakthrough designation.

Under a separate pathway known as "accelerated approval" drugs may be approved based on a so-called surrogate endpoint - a measure, such as tumor shrinkage - that might reasonably be expected to confer a clinical benefit such as improved survival.

Companies that win approval for a product under the accelerated approval process are required subsequently to prove through further clinical trials that the surrogate measure does in fact correlate with improved survival or a reduction in disease symptoms.

"A discussion on this topic is reckless if it doesn't discuss the next stage after the drug reaches the market," said Sidney Wolfe, co-founder and senior adviser to Public Citizen's Health Research Group, a watchdog organization that has frequently criticized the FDA for approving, or failing to withdraw, drugs it considers unsafe.

Woodcock said the FDA is now working to develop a mechanism to speed the development of breakthrough diagnostics that can be used in conjunction with new drugs to help identify which patients will respond to a particular therapy.

(This refile corrects paragraph 5 to shows Kalydeco was given designation after, not before, approval)

(Reporting by Toni Clarke; Editing by Ros Krasny and Lisa Shumaker)

Source: http://news.yahoo.com/drugmakers-cheer-speed-lane-breakthrough-therapies-173049177.html

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Jailed russian female punk rock member loses parole appeal

PERM, Russia (Reuters) - A member of Russian female punk group Pussy Riot lost her appeal for parole on Wednesday after nearly a year in prison for performing a protest song against President Vladimir Putin in a Moscow cathedral.

Maria Alyokhina's appeal against a previous decision to deny her early release from a two-year jail sentence was rejected by a court in the city of Perm, where she is serving her sentence, about 1,500 km (940 miles) east of Moscow.

Alyokhina, 25, and two other Pussy Riot members were convicted of hooliganism motivated by religious hatred in August for bursting into the Russian Orthodox cathedral and belting out a "punk prayer" asking the Virgin Mary to rid Russia of Putin.

Madonna, Paul McCartney and Adele were among more than 100 musicians to sign a letter calling for their release that was published by Amnesty International on Tuesday.

The rights watchdog said Wednesday's ruling was "a further confirmation that the Russian authorities are uncompromising in their suppression of freedom of expression".

The case is seen as part of a wider crackdown on protests since Putin returned to the Kremlin for a third term in 2012.

Alyokhina and Nadezhda Tolokonnikova, 23, are due for release in March. Both mothers of five-year-olds were denied pleas for a deferred sentence until their children are older.

A third member of the feminist group, Yekaterina Samutsevich, was freed last October when a judge suspended her sentence on appeal.

(Reporting by Catherine Koppel; Writing by Alissa de Carbonnel; Editing by Raissa Kasolowsky)

Source: http://news.yahoo.com/jailed-russian-female-punk-rock-member-loses-parole-150253449.html

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Tuesday, July 23, 2013

Madagascar police fire teargas at opposition protesters

ANTANANARIVO (Reuters) - Police in Madagascar fired teargas on Monday at supporters of a political party opposed to the transitional government of President Andry Rajoelina, demanding immediate elections and his departure.

The former French colony has been in crisis since 2009 when Rajoelina took power with military support, ousting former President Marc Ravalomanana and triggering turmoil that scared off investors and tourists.

The main political parties signed a road map in 2011, mediated by the Southern African Development Community, which confirmed Rajoelina as president and allowed for the unconditional return of Ravalomanana from self-imposed exile.

Rajoelina and Ravalomanana had reached a deal with regional states not to run in this year's poll. But when Ravalomanana's wife, Lalao Ravalomanana, chose to run, Rajoelina said the pact had broken down and put his name forward.

As a result, foreign donors suspended election financing and the government had to postpone the vote by a month to August 23.

The African Union said on Friday Rajoelina had failed to heed its calls to withdraw, casting doubt on whether the poll would take place.

Hundreds of supporters of the Avotr'i Madagasikara party gathered in the capital to demand the running of the vote. Police fired teargas to disperse them. They later regrouped and threatened to protest again on Tuesday.

"We want elections to take place as soon as possible. We want the transitional government, starting with Andry Rajoelina, to leave," protester Leontine Randrianantenaina said.

Rajoelina flew to Tanzania on Monday to meet President Jakaya Kikwete, who chairs a Southern African Development Community grouping on politics, security and peace, to discuss the political situation on the island.

Source: http://news.yahoo.com/madagascar-police-fire-teargas-opposition-protesters-061608431.html

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Genesis Energy Buys a Fleet

Genesis Energy (NYSE: GEL??) has added 18 vessels to its list of assets. The partnership announced that it has inked an agreement to acquire the downstream transportation business of Hornbeck Offshore Transportation (NYSE: HOS??) , which is essentially composed of those vessels. The price is roughly $230 million.

For its money, Genesis Energy will be buying nine barges and an equal number of tugboats. All are used to ship crude oil and refined products, and service refineries and storage terminals on the Gulf Coast and Eastern Seaboard, as well as on the Great Lakes and the Caribbean Sea.

At the moment, the company's inland barge operations are serviced by 50 barges and 23 push/tow boats.

The acquisition is subject to approval from the relevant regulatory bodies and is expected to close by the end of Q3. Genesis Energy said it will fund the transaction from its $1 billion revolving credit facility.

Once that occurs, said the partnership, it and Hornbeck "expect to enter into transition service agreements to facilitate a smooth transition of operations and uninterrupted services for both employees and customers."

The company said it anticipated that the new assets would be "immediately accretive" to its distributable cash flow per unit.

Source: http://feeds.fool.com/~r/usmf/foolwatch/~3/JrHYWbLaCGU/story01.htm

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